Best Aromatase Inhibitors for Bodybuilding and Estrogen Management

The next family in the anabolic steroid family tree is Dihydrotestosterone (DHT) and DHT derivatives. The theoretical 3-D model of human aromatase based on the crystal structure of human P450 2C9 7 provides useful structural information and a reliable structural basis for ligand docking. In this model, the heme iron is ligated by a conserved cysteine (C437), and the propionates of heme interact with the side chain of residues R115, W141, R145, R375, and R435. I125-P138 of the B′-C loop penetrates into the interior of the molecule so that residues I132-F134 are located in or adjacent to the active site. The β4 sheet protrudes into the active site, placing residues L477-H480 above the active site pocket. Together with D309 (in the I helix), S478 and H480 (in the β4 sheet) are thought to participate in a charge relay system that leads to the aromatization of the A ring of androgen.

Breastfeeding

You might also have questions such as how much Arimidex would be taken with 200 mg of testosterone or the differences between Arimidex versus Aromasin. Your doctor can help answer your questions and determine whether Arimidex is safe for you. To learn about some of the side effects listed here and how to manage them, seeManaging Cancer-related Side Effects.

It is easier to predict the interaction of steroidal inhibitors such as exemestane with aromatase than to predict the interaction of nonsteroidal inhibitors with the enzyme. The binding of exemestane to aromatase has been extensively discussed in a previous publication 9. There have been a number of modeling studies on triazole derivative inhibitors, including anastrozole, letrozole, and vorozole.

Taking Arimidex

• Preventive Services Task Force list exemestane and anastrozole as risk-reducing drug options for postmenopausal women at high risk of breast cancer.
• Oestrogens play an important role in epididymal function and sperm maturation 35, 47, 48.
• Complete recovery of testosterone function is your number one goal of PCT.
• Nolvadex should be used during the cycle with compounds like Dianabol and Anadrol.
• Learn more about ovarian suppression and aromatase inhibitors.

But it’s the topic of post-cycle therapy (PCT) that I get questions about most often!! PCT is usually essential for recovering from a steroid cycle1 and getting your natural testosterone levels back to where they should be. But it’s not only needed for steroids… SARMs and other PEDs can also be suppressive and require post-cycle therapy and/or on-cycle mitigation for the nasty side effects they produce. This aromatase inhibitor surpasses exemestane and anastrozole as being the most potent AI used today by bodybuilders. It has shown an ability to not only prevent gynocomastia, but to reduce current cases of gyno.

You’ll use RU by applying it directly where it’s needed, and it works in those specific spots by blocking those androgen receptors. This allows you to target acne and hair loss as and when needed. You won’t get any symptoms of low DHT because your levels are not suppressed when using RU-58841.

For the estrogen receptor–positive breast cancer patient who will be starting nonsteroidal AI therapy such as anastrozole or letrozole, the list of major interactions is short and largely manageable by monitoring. One of the interactions that can be seen in this population is the concurrent use of methadone for chronic pain control. CYP19, an aromatase enzyme, theoretically plays a role in the metabolism of methadone.

Aromatase Inhibitors (AI) (15 Offers)

But the muscle and joint pain has led some women to stop treatment. If this happens, most doctors recommend using tamoxifen to complete 5 to 10 years of hormone treatment. Aromatase inhibitors (AIs) are a critical part of any serious post-cycle therapy or on-cycle estrogen management plan. These compounds work by blocking the aromatase enzyme responsible for converting testosterone into estrogen. When estrogen levels rise too high during a steroid cycle, users can experience bloating, gynecomastia (development of breast tissue in men), water retention, and mood fluctuations.

Patients should also have a baseline bone mineral density test (DEXA scan) before initiating the treatment 6, 7. Dragon Pharma offers pharmaceutical-grade AIs such as Anastrozole, Letrozole, and Exemestane. These compounds are widely used by bodybuilders and performance athletes to maintain a dry, lean look and avoid the common side effects of estrogen dominance.

In the aromatase knockout (ArKO), follicle development is arrested at a stage before ovulation and no corpora lutea are formed 15. Moreover, although ArKO mice contain follicles at all stages of development, antral follicles are abnormal, presenting blood-filled antra and high levels of apoptosis in granulosa cells 16. In ERβ knockout mice, on the other hand, antral follicles are normal, but aromatase expression is significantly decreased 17. In the ovary, the substrate for aromatase is produced by the theca cells of https://www.stockersshop.com/drostanolone-enanthate-200-mg-cygnus-an-overview-3/ the follicle. Theca cell–derived androgens are also directly involved in the regulation of this enzyme.